SCHEMBL83771

SCHEMBL83771

C#CC(C)[O]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4226099 0.73
SCHEMBL11333386 0.73
SCHEMBL3002003 0.72
SCHEMBL712153 0.72
SCHEMBL23741 0.70
SCHEMBL11244260 0.70
SCHEMBL4949573 0.67
SCHEMBL10983922 0.67
SCHEMBL15438159 0.67
SCHEMBL2870228 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1011 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11548903-B2 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use AMGEN INC. (US) 2023-01-10 US claimed
EP-3555106-B1 BICYCLIC THIAZINE AND OXAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC (US) 2022-03-09 EP claimed
US-11021493-B2 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use AMGEN INC. (US) 2021-06-01 US claimed
US-20200231601-A1 1,4-THIAZINE DIOXIDE AND 1,2,4-THIADIAZINE DIOXIDE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. (US) 2020-07-23 US claimed
US-20200199153-A1 BICYCLIC THIAZINE AND OXAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. (US) 2020-06-25 US claimed
EP-3555086-A1 1,4-THIAZINE DIOXIDE AND 1,2,4-THIADIAZINE DIOXIDE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE Amgen Inc. (US) 2019-10-23 EP claimed
EP-3555106-A1 BICYCLIC THIAZINE AND OXAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE Amgen Inc. (US) 2019-10-23 EP claimed
WO-2018112084-A1 BICYCLIC THIAZINE AND OXAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. (US) 2018-06-21 WO claimed
WO-2018112094-A1 1,4-THIAZINE DIOXIDE AND 1,2,4-THIADIAZINE DIOXIDE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. (US) 2018-06-21 WO claimed
US-8168668-B2 Compounds ASTRAZENECA AB (SE) 2012-05-01 US claimed
US-20100286202-A1 New Compounds ASTRAZENECA AB (SE) 2010-11-11 US claimed
WO-2010055077-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS FUNGICIDES BAYER CROPSCIENCE SA (FR) 2010-05-20 WO claimed
US-20080171770-A1 Compounds ASTRAZENECA AB (SE) 2008-07-17 US claimed
US-5612289-A 4-imino-oxazolidine-2-one derivatives, a process for producing such derivatives and a herbicide containing them as an active ingredient SAGAMI CHEMICAL RESEARCH CENTER (JP) 1997-03-18 US claimed
EP-0722939-A1 4-IMINOOXAZOLIDIN-2-ONE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT SAGAMI CHEMICAL RESEARCH CENTER (JP) 1996-07-24 EP claimed
US-5518994-A 2-arylaminopyrimidinone derivative, and herbicide and plant growth regulator NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-21 US claimed
EP-0415642-B1 Glutarimides ROHM & HAAS (US) 1995-12-06 EP claimed
US-5393735-A N-(halo-oxy-)phenyl substituted cyclic imides ROHM AND HAAS COMPANY (US) 1995-02-28 US claimed
EP-0636615-A1 2-ARYLAMINOPYRIMIDINONE DERIVATIVE, AND HERBICIDE AND PLANT GROWTH REGULATOR NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1995-02-01 EP claimed
EP-0125901-B1 FUNGICIDAL ANILINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-02-08 EP claimed