⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30159553 | 1.00 | — | — | |
| SCHEMBL9355983 | 0.74 | HDAC8 (0.37) | — | |
| SCHEMBL15772630 | 0.73 | HDAC8 (0.33) | — | |
| Hydrochloric Acid SCHEMBL15772225 | 0.73 | — | — | |
| SCHEMBL15772610 | 0.73 | — | — | |
| SCHEMBL28028661 | 0.73 | — | — | |
| SCHEMBL9355988 | 0.72 | HDAC8 (0.34) | — | |
| SCHEMBL9799696 | 0.72 | — | — | |
| SCHEMBL3881120 | 0.70 | — | — | |
| SCHEMBL19358691 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006232-B2 | Pyrimidone derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-04-14 | — | — | US | disclosed |
| EP-1827434-B1 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8569294-B2 | 2-(cyclic amino)-pyrimidone derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-10-29 | — | — | US | disclosed |
| US-20120208797-A1 | PYRIMIDONE DERIVATIVES | SANOFI (FR) | 2012-08-16 | — | — | US | disclosed |
| EP-2464632-A1 | PYRIMIDONE DERIVATIVES USED AS TAU PROTEIN KINASE 1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-06-20 | — | — | EP | disclosed |
| US-8129377-B2 | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |
| EP-2423207-A2 | 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-8106045-B2 | 2-morpholino-4-pyrimidone compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-01-31 | — | — | US | disclosed |
| EP-1805164-B9 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-09-07 | — | — | EP | disclosed |
| EP-1805164-B1 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-02-23 | — | — | EP | disclosed |
| EP-1454910-A1 | Substituted pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidone derivatives | SANOFI-SYNTHELABO (FR) | 2004-09-08 | — | — | EP | disclosed |
| EP-1454908-A1 | Substituted pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinone derivatives | SANOFI-SYNTHELABO (FR) | 2004-09-08 | — | — | EP | disclosed |
| US-6653317-B2 | Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss | SOCIETE L'OREAL S.A. (FR) | 2003-11-25 | — | — | US | disclosed |
| US-6511659-B2 | Treatment of alopecia, cosmetics | SOCIETE L'OREAL S.A. (FR) | 2003-01-28 | — | — | US | disclosed |
| EP-0836602-B1 | FUNGICIDAL PYRIMIDINONES | DU PONT (US) | 2002-01-30 | — | — | EP | disclosed |
| US-6291468-B1 | Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss | SOCIETE L'OREAL S.A. (FR) | 2001-09-18 | — | — | US | disclosed |
| US-6245770-B1 | AGRICULTURE | E. I. DU PONT DE NEMOURS AND COMPANY | 2001-06-12 | — | — | US | disclosed |
| US-6066638-A | CONTROLLING PLANT DISEASES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-05-23 | — | — | US | disclosed |
| EP-0836602-A1 | FUNGICIDAL PYRIMIDINONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002262-A1 | FUNGICIDAL PYRIMIDINONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-01-23 | — | — | WO | disclosed |