Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | PRCP | P42785 | 1/20 | 0.30 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8374387 | 0.84 | HTR2A (0.36) | HTR2AHTR2CHRH1PRCP | |
| SCHEMBL8378073 | 0.80 | HTR2A (0.36) | HTR2AHTR2CHRH1TBXA2RPRCP | |
| SCHEMBL8375640 | 0.76 | TBXA2R (0.35) | HTR2AHTR2CHRH1TBXA2R | |
| SCHEMBL11614868 | 0.71 | HTR2A (0.40) | HTR2AHTR2CHRH1 | |
| SCHEMBL11837204 | 0.71 | HTR2A (0.42) | HTR2AHTR2CHRH1PRCP | |
| SCHEMBL10188320 | 0.70 | HTR2A (0.44) | HTR2AHTR2CHRH1PRCP | |
| SCHEMBL11845155 | 0.68 | HTR2A (0.64) | HTR2AHTR2CHRH1PRCP | |
| SCHEMBL8353004 | 0.68 | HTR2A (0.39) | HTR2AHTR2CHRH1TBXA2R | |
| SCHEMBL8375617 | 0.68 | HTR2A (0.38) | HTR2AHTR2CHRH1 | |
| SCHEMBL9331557 | 0.67 | HTR2A (0.43) | HTR2AHTR2CHRH1TBXA2RLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733049-B1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORP (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5574173-A | INHIBITORS OF TUMOR NECROSIS FACTOR | SCHERING CORPORATION (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0733049-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015959-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |