Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.43 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.43 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664470 | 1.00 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20107264 | 0.82 | BCHE (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL26759652 | 0.81 | SSTR1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9306587 | 0.81 | SSTR1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19188801 | 0.81 | SSTR1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27304154 | 0.80 | BCHE (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8714375 | 0.80 | BCHE (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5804280 | 0.80 | BCHE (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8382578 | 0.79 | BCHE (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8718077 | 0.78 | SLC6A2 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749976-B1 | ANTHRACYCLINE DERIVATIVES CONTAINING TRIFLUOROMETHYLATED SUGAR UNIT | ZAIDAN HOJIN BISEIBUTSU (JP) | 1999-04-28 | — | — | EP | disclosed |
| EP-0761678-B1 | Fluorine-containing anthracycline derivatives having hydroxyl group(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof | ZAIDAN HOJIN BISEIBUTSU (JP) | 1999-03-31 | — | — | EP | disclosed |
| US-5801257-A | DAUNOMYCIN ANTITUMOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5789386-A | WATER SOLUBLE ANTITUMOR AGENTS; INJECTABLE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1998-08-04 | — | — | US | disclosed |
| US-5719130-A | HIGH ANTITUMOR ACTIVITY, LOWER TOXICITY | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0761678-A1 | Fluorine-containing anthracycline derivatives having hydroxyl group(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1997-03-12 | — | — | EP | disclosed |
| EP-0749976-A1 | NOVEL ANTHRACYCLINE DERIVATIVES CONTAINING TRIFLUOROMETHYLATED SUGAR UNIT | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-12-27 | — | — | EP | disclosed |