Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29168313 | 1.00 | JAK3 (0.39) | JAK3BTKGRNSORT1MAPK1 | |
| SCHEMBL12396347 | 0.85 | JAK3 (0.50) | JAK3BTKCYP2C9 | |
| SCHEMBL2569629 | 0.85 | JAK3 (0.50) | JAK3BTKCYP2C9 | |
| SCHEMBL16164638 | 0.83 | CA12 (0.35) | JAK3BTKFAAH | |
| SCHEMBL25360128 | 0.81 | JAK3 (0.38) | JAK3BTKGRNSORT1FAAH | |
| SCHEMBL25360136 | 0.81 | JAK3 (0.38) | JAK3BTKGRNSORT1FAAH | |
| SCHEMBL18989374 | 0.80 | JAK3 (0.34) | JAK3BTK | |
| SCHEMBL1807815 | 0.80 | JAK3 (0.34) | JAK3BTK | |
| SCHEMBL16164513 | 0.79 | JAK3 (0.33) | JAK3BTKFAAH | |
| SCHEMBL838395 | 0.78 | JAK3 (0.35) | JAK3BTKFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117529476-A | Preparation of substituted 1, 2-diamino heterocyclic derivatives and their use as medicaments | 亚飞络思制药公司 | 2024-02-06 | — | — | CN | disclosed |
| US-5973188-A | Acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-10-26 | — | — | US | disclosed |