Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.59 |
| ▸ | RORC | P51449 | 2/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.43 |
| ▸ | FPR2 | P25090 | 4/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82171 | 1.00 | NR1H2 (0.59) | NR1H2NR1H3RORCABHD6ROCK2 | |
| SCHEMBL1673567 | 1.00 | NR1H2 (0.59) | NR1H2NR1H3RORCABHD6ROCK2 | |
| SCHEMBL82172 | 0.93 | NR1H2 (0.57) | NR1H2NR1H3RORCABHD6ROCK2 | |
| SCHEMBL12988184 | 0.93 | NR1H2 (0.57) | NR1H2NR1H3RORCABHD6ROCK2 | |
| SCHEMBL22772313 | 0.88 | NR1H2 (0.47) | NR1H2NR1H3RORCABHD6ROCK2 | |
| SCHEMBL521801 | 0.87 | NR1H2 (0.49) | NR1H2NR1H3RORCABHD6ROCK2 | |
| SCHEMBL83391 | 0.87 | MEN1 (0.53) | NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL1673737 | 0.87 | MEN1 (0.53) | NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL1673736 | 0.87 | MEN1 (0.53) | NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL4712983 | 0.87 | NR1H2 (0.58) | NR1H2NR1H3RORCABHD6ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805164-B9 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-09-07 | — | — | EP | disclosed |
| EP-1805164-B1 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-02-23 | — | — | EP | disclosed |