⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790981 | 0.78 | — | — | |
| SCHEMBL3988597 | 0.74 | — | — | |
| SCHEMBL16785658 | 0.74 | — | — | |
| SCHEMBL92520 | 0.74 | — | — | |
| SCHEMBL1837583 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL17477505 | 0.72 | — | — | |
| SCHEMBL9371681 | 0.70 | — | — | |
| SCHEMBL1303616 | 0.70 | — | — | |
| SCHEMBL1148587 | 0.70 | CA1 (0.37) | — | |
| SCHEMBL8709733 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109293664-A | Pyrimido 1,2,4- triazole hydrazine class compound and its preparation method and application | 郑州大学 | 2019-02-01 | — | — | CN | claimed |
| WO-2018151937-A1 | VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2018-08-23 | — | — | WO | claimed |
| CN-1051174-A | Triazolo derivatives and preparation method thereof | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1991-05-08 | — | — | CN | claimed |
| CN-1050191-A | New thiazole derivative, they the preparation method and contain their pharmaceutical composition | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-03-27 | — | — | CN | claimed |
| US-20230227470-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | VANDERBILT UNIVERSITY | 2023-07-20 | — | — | US | disclosed |
| US-11602531-B2 | Vacuole-inducing compounds, methods of making and using the same | THE UNIVERSITY OF TOLEDO (US) | 2023-03-14 | — | — | US | disclosed |
| US-11602531-B2 | Vacuole-inducing compounds, methods of making and using the same | THE UNIVERSITY OF TOLEDO (US) | 2023-03-14 | — | — | US | disclosed |
| US-20210038586-A1 | VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-02-11 | — | — | US | disclosed |
| US-20210038586-A1 | VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-02-11 | — | — | US | disclosed |
| CN-109293664-A | Pyrimido 1,2,4- triazole hydrazine class compound and its preparation method and application | 郑州大学 | 2019-02-01 | — | — | CN | disclosed |
| WO-2018151937-A1 | VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2018-08-23 | — | — | WO | disclosed |
| WO-2018151937-A1 | VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2018-08-23 | — | — | WO | disclosed |
| US-5665394-A | Matrix for sustained-release preparation | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-09 | — | — | US | disclosed |
| US-5594091-A | POLYLACTONES FOR MICROCAPSULES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| US-5582900-A | A TRIAZOLE-METAL COMPLEXES; HYSTERESIS, THERMOLUMINESCENCE; COMPUTER SCREEN | U.S. PHILIPS CORPORATION (US) | 1996-12-10 | — | — | US | disclosed |
| US-5567819-A | Process for preparing indole derivatives containing a 1,2,4-triazol-1-yl substituent | MERCK, SHARP & DOHME, LTD. (GB) | 1996-10-22 | — | — | US | disclosed |
| EP-0668073-A2 | Polyester matrix for a pharmaceutical sustained-release preparation | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |
| EP-0651748-A1 | PROCESS FOR PREPARING INDOLE DERIVATIVES CONTAINING A 1,2,4-TRIAZOL-1-YL SUBSTITUENT. | MERCK SHARP & DOHME (GB) | 1995-05-10 | — | — | EP | disclosed |
| CN-1085555-A | Process for preparing indole derivatives containing 1, 2, 4-triazol-1-yl substituents | MERCK SHARP & DOHME (GB) | 1994-04-20 | — | — | CN | disclosed |
| WO-1994002476-A1 | PROCESS FOR PREPARING INDOLE DERIVATIVES CONTAINING A 1,2,4-TRIAZOL-1-YL SUBSTITUENT | MERCK SHARP & DOHME LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |