Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5748951 | 0.91 | HTR1B (0.54) | HTR1BHTR2BGPR65KDM4EATM | |
| Fumaric Acid SCHEMBL5748946 | 0.91 | HTR1B (0.54) | HTR1BHTR2BGPR65KDM4EATM | |
| SCHEMBL5749566 | 0.91 | HTR1B (0.60) | HTR1BHTR2BGPR65KDM4EATM | |
| SCHEMBL5749638 | 0.88 | HTR1B (0.58) | HTR1BHTR2BGPR65KDM4EATM | |
| Bromide SCHEMBL8386216 | 0.88 | HTR1B (0.58) | HTR1BHTR2BGPR65KDM4EATM | |
| Hydrochloric Acid SCHEMBL7132300 | 0.88 | HTR1B (0.58) | HTR1BHTR2BGPR65KDM4EATM | |
| Hydrochloric Acid SCHEMBL5750473 | 0.88 | HTR1B (0.58) | HTR1BHTR2BGPR65KDM4EATM | |
| SCHEMBL5750582 | 0.88 | HTR1B (0.63) | HTR1BHTR2BGPR65KDM4EATM | |
| SCHEMBL5749037 | 0.87 | HTR1B (0.57) | HTR1BHTR2BGPR65KDM4EATM | |
| Hydrochloric Acid SCHEMBL5772441 | 0.86 | HTR1B (0.56) | HTR1BHTR2BGPR65KDM4ESOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958934-A | 5-HT 2B ANTAGONIST | SYNTEX (U.S.A.) INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5952331-A | SELECTIVE 5HT2B ANTAGONISTS; SEROTONIN RECEPTOR ANTAGONIST; TREATING DISORDERS OF THE GASTROINTESTINAL TRACK, RESTENOSIS, ASTHMA AND OBSTRUCTIVE AIRWAY DISEASE, PROSTATIC HYPERPLASIA, GENERALIZED ANXIETY, PANIC DISORDER | SYNTEX (USA) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5863924-A | Aryl pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1999-01-26 | — | — | US | disclosed |