Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 9/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8706532 | 0.99 | GGPS1 (0.63) | GGPS1LMNAHSP90AA1HTTSMN1; SMN2 | |
| SCHEMBL8705848 | 0.99 | GGPS1 (0.63) | GGPS1LMNAHSP90AA1HTTSMN1; SMN2 | |
| SCHEMBL8707819 | 0.87 | GGPS1 (0.60) | GGPS1LMNAHSP90AA1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8467992 | 0.86 | GGPS1 (0.59) | GGPS1LMNAHSP90AA1HTTSMN1; SMN2 | |
| SCHEMBL12257807 | 0.82 | GGPS1 (0.86) | GGPS1FDPS | |
| SCHEMBL12060529 | 0.82 | GGPS1 (0.86) | GGPS1FDPS | |
| SCHEMBL12060539 | 0.82 | GGPS1 (0.86) | GGPS1FDPS | |
| SCHEMBL5290533 | 0.79 | HDAC1 (0.61) | GGPS1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5308023 | 0.79 | HDAC1 (0.61) | GGPS1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5302637 | 0.79 | HDAC1 (0.57) | LMNAHSP90AA1HTTSMN1; SMN2RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650361-B1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMA (US) | 1999-04-28 | — | — | EP | claimed |
| US-5869471-A | Methods for the treatment of arthritis using phosphonates and NSAIDS | THE PROCTOR & GAMBLE COMPANY (US) | 1999-02-09 | — | — | US | claimed |
| EP-0650361-A1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-05-03 | — | — | EP | claimed |
| WO-1994000130-A1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1994-01-06 | — | — | WO | claimed |
| EP-0650361-B1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMA (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0646119-B1 | QUATERNARY NITROGEN-CONTAINING PHOSPHONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM AS WELL AS DENTAL CALCULUS AND PLAQUE | PROCTER & GAMBLE PHARMA (US) | 1998-07-15 | — | — | EP | disclosed |
| EP-0849272-A1 | Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque | Procter & Gamble Pharmaceuticals, Inc. (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5770586-A | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism amd methods of treating and preventing dental calculus and plaque | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0646119-A1 | QUATERNARY NITROGEN-CONTAINING PHOSPHONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM AS WELL AS DENTAL CALCULUS AND PLAQUE | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5391743-A | Treating osteoporosis, rheumatoid arthritis, osteoarthritis | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-02-21 | — | — | US | disclosed |
| WO-1993024498-A1 | QUATERNARY NITROGEN-CONTAINING PHOSPHONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM AS WELL AS DENTAL CALCULUS AND PLAQUE | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-12-09 | — | — | WO | disclosed |