Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.71 |
| ▸ | EDNRB | P24530 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058051 | 0.83 | EDNRA (1.00) | EDNRA | |
| SCHEMBL8392365 | 0.81 | EDNRA (0.53) | EDNRAEDNRBMAPTHCRTR1ALDH1A1 | |
| SCHEMBL8391081 | 0.78 | EDNRA (0.70) | EDNRAEDNRBMAPTHCRTR1ALDH1A1 | |
| SCHEMBL7768597 | 0.76 | EDNRA (0.71) | EDNRAEDNRBMAPTHCRTR1PKM | |
| SCHEMBL8394178 | 0.76 | EDNRA (0.67) | EDNRAEDNRBHCRTR1ALDH1A1RXFP1 | |
| SCHEMBL8390511 | 0.74 | EDNRA (0.55) | EDNRAEDNRBHCRTR1ALDH1A1RXFP1 | |
| SCHEMBL7770278 | 0.73 | EDNRA (0.54) | EDNRAEDNRBMAPTHCRTR1ALDH1A1 | |
| SCHEMBL8394999 | 0.72 | EDNRA (0.73) | EDNRAEDNRBMAPTHCRTR1 | |
| SCHEMBL8392558 | 0.72 | EDNRA (0.59) | EDNRAEDNRBHCRTR1 | |
| SCHEMBL8391095 | 0.72 | EDNRA (0.76) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752986-B1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LTD (GB) | 1999-05-19 | — | — | EP | disclosed |