Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392442 | 1.00 | HTT (0.72) | HTTALDH1A1MAPTKMT2APOLB | |
| SCHEMBL30423567 | 1.00 | HTT (0.72) | HTTALDH1A1MAPTKMT2APOLB | |
| SCHEMBL8395012 | 0.98 | HTT (0.69) | HTTALDH1A1MAPTKMT2APOLB | |
| Bicarbonate SCHEMBL15226014 | 0.96 | HTT (0.68) | HTTALDH1A1MAPTKMT2APOLB | |
| SCHEMBL18629069 | 0.95 | HTT (0.71) | HTTALDH1A1MAPTKMT2APOLB | |
| SCHEMBL8393830 | 0.94 | HTT (0.63) | HTTALDH1A1MAPTKMT2APOLB | |
| SCHEMBL2953579 | 0.90 | HTT (0.57) | HTTALDH1A1MAPTKMT2APOLB | |
| SCHEMBL27979494 | 0.86 | HTT (0.88) | HTTALDH1A1POLBNPSR1KDM4E | |
| SCHEMBL8392088 | 0.84 | HTT (1.00) | HTTALDH1A1POLBNPSR1KDM4E | |
| SCHEMBL13380 | 0.84 | HTT (1.00) | HTTALDH1A1POLBNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |