Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.50 |
| ▸ | CHRNG | P07510 | 1/20 | 0.50 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | CHRND | Q07001 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507979 | 0.85 | PARP1 (0.57) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL9040297 | 0.83 | PARP1 (0.60) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL1024046 | 0.83 | SLC6A2 (0.55) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL5483483 | 0.79 | PARP1 (0.60) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL8400086 | 0.79 | SMYD3 (0.47) | — | |
| SCHEMBL1024675 | 0.79 | TDP1 (0.51) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL11068002 | 0.79 | PARP1 (0.55) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL9559781 | 0.79 | PARP1 (0.55) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL5205446 | 0.79 | PARP1 (0.50) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL25247146 | 0.79 | PARP1 (0.59) | PARP1SLC6A2SLC6A3CHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663899-B1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | UNIV MARYLAND (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0919538-A1 | Substituted kynurenines, a process for their preparation, and use as medicaments | THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5786508-A | ENZYME INHIBITOR; COGNITION ACTIVATOR | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-07-28 | — | — | US | disclosed |
| US-5708030-A | COGNITION ACTIVATORS, PERINATAL BRAIN DISORDERS | UNIVERSITY OF MARYLAND (US) | 1998-01-13 | — | — | US | disclosed |
| US-5519055-A | ENZYME INHIBITORS | UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0663899-A4 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS. | UNIV MARYLAND (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0663899-A1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1995-07-26 | — | — | EP | disclosed |
| WO-1995004714-A1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1995-02-16 | — | — | WO | disclosed |