SCHEMBL8397642

SCHEMBL8397642

CCP(=O)(CC)C(=O)c1ccccc1C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.46
ERCC5 P28715 1/20 0.44
FEN1 P39748 1/20 0.44
SMN1; SMN2 Q16637 5/20 0.43
KMT2A Q03164 3/20 0.43
GAA P10253 3/20 0.42
TSHR P16473 2/20 0.42
MAPK1 P28482 2/20 0.42
ALDH1A1 P00352 3/20 0.42
MAPT P10636 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
DHODH Q02127 1/20 0.41
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
THRB P10828 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
KDM4E B2RXH2 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL778868 0.83 HPGD (0.49) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL2258548 0.79 HPGD (0.52) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL443122 0.79 HPGD (0.52) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL8401161 0.78 SMN1; SMN2 (0.46) SMN1; SMN2KMT2AALDH1A1MAPTMEN1
SCHEMBL779190 0.78 HPGD (0.50) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL10092049 0.78 KMT2A (0.49) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL779439 0.77 KMT2A (0.58) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL778657 0.77 KMT2A (0.51) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL1034215 0.74 HPGD (0.47) HPGDERCC5FEN1SMN1; SMN2KMT2A
SCHEMBL776757 0.74 KMT2A (0.49) HPGDERCC5FEN1SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5916495-A COMPRISING POLYMETHYL METHACRYLATE AND A CLADDING LAYER; VARYING REFRACTIVE INDEX SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-06-29 US disclosed
US-5891570-A Plastic optical fiber preform having a jacket layer SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-04-06 US disclosed
US-5851666-A Plastic optical fiber preform, and process and apparatus for producing the same SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1998-12-22 US disclosed
US-5639512-A REFRACTIVE INDEX GRADIENTS SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-06-17 US disclosed
US-5614253-A DEPOSITING POLYMER LAYER WITH REFRACTIVE INDEX MODIFIER SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-03-25 US disclosed
EP-0664463-A1 PLASTIC OPTICAL FIBER BASE MATERIAL, PRODUCTION METHOD THEREFOR, AND APPARATUS THEREFOR SUMITOMO ELECTRIC INDUSTRIES, LIMITED (JP) 1995-07-26 EP disclosed
EP-0662620-A1 PRODUCTION METHOD AND APPARATUS FOR PLASTIC OPTICAL FIBER BASE MATERIAL SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1995-07-12 EP disclosed