⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537266 | 1.00 | — | — | |
| SCHEMBL6056388 | 0.92 | — | — | |
| SCHEMBL6056382 | 0.87 | — | — | |
| SCHEMBL7619698 | 0.86 | CAPN1 (0.35) | — | |
| SCHEMBL5891962 | 0.84 | FNTB (0.37) | — | |
| SCHEMBL7628039 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL8726874 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL5571191 | 0.83 | — | — | |
| SCHEMBL6056455 | 0.82 | FNTB (0.39) | — | |
| SCHEMBL7628171 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998043629-A1 | ANTI-INFLAMMATORY MEDICAMENT CONTAINING FARNESYL PROTEIN TRANSFERASE INHIBITOR, ITS PREPARATION AND USE | FERRING B.V. (NL) | 1998-10-08 | — | — | WO | claimed |
| EP-0535730-A2 | Inhibitors of farnesyl protein transferase | MERCK & CO. INC. (US) | 1993-04-07 | — | — | EP | claimed |
| US-20130225671-A1 | Methods of Treating Seizure Disorders | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225671-A1 | Methods of Treating Seizure Disorders | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-29 | — | — | US | disclosed |
| WO-2012054724-A1 | METHODS OF TREATING SEIZURE DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-04-26 | — | — | WO | disclosed |
| US-5990277-A | ANTICARCINOGENIC/ANTITUMOR/ANTIPROLIFERATIVE AGENTS AGAINST ONCOGENIC OR NON-ONCOGENIC RAS ASSOCIATED CANCERS AND PROLIFERATIVE DISORDERS; DERIVED FROM UNIVERSAL RECOGNITION TETRAPEPTIDE SEQUENCE CAAX | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HERBREW UNIVERSITY OF JERUSALEM (IL) | 1999-11-23 | — | — | US | disclosed |
| WO-1998043629-A1 | ANTI-INFLAMMATORY MEDICAMENT CONTAINING FARNESYL PROTEIN TRANSFERASE INHIBITOR, ITS PREPARATION AND USE | FERRING B.V. (NL) | 1998-10-08 | — | — | WO | disclosed |
| US-5480893-A | ANTITUMOR | MERCK & CO., INC. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5340828-A | Anticarcinogenic agents | MERCK & CO., INC. (US) | 1994-08-23 | — | — | US | disclosed |
| EP-0535730-A2 | Inhibitors of farnesyl protein transferase | MERCK & CO. INC. (US) | 1993-04-07 | — | — | EP | disclosed |