Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936829 | 0.85 | TSHR (0.40) | TSHR | |
| SCHEMBL6161515 | 0.81 | — | — | |
| SCHEMBL22631157 | 0.80 | TSHR (0.43) | TSHR | |
| SCHEMBL1260379 | 0.77 | — | — | |
| SCHEMBL27522982 | 0.77 | — | — | |
| SCHEMBL11223644 | 0.77 | — | — | |
| SCHEMBL11336671 | 0.77 | — | — | |
| SCHEMBL6542359 | 0.76 | TSHR (0.42) | TSHRALDH1A1 | |
| SCHEMBL11139855 | 0.76 | TSHR (0.33) | TSHRTHRB | |
| SCHEMBL4534601 | 0.74 | TSHR (0.32) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36374-E | 1,2,3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists | H. LUNDBECK, A/S (DK) | 1999-11-02 | — | — | US | disclosed |
| EP-0296721-B1 | HETEROCYCLIC COMPOUNDS | H. LUNDBECK A/S (DK) | 1993-06-23 | — | — | EP | disclosed |
| EP-0336555-B1 | 4,5,6,7-TETRAHYDROISOTHIAZOLO (4,5-C)PYRIDINE DERIVATIVES AND ISOMERS | H. LUNDBECK A/S (DK) | 1992-09-30 | — | — | EP | disclosed |
| US-4925858-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1990-05-15 | — | — | US | disclosed |
| US-4923880-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE; ACETYLCHOLINE OR MUSCARINE AGONISTS | H. LUNDBECK A/S (DK) | 1990-05-08 | — | — | US | disclosed |
| EP-0336555-A1 | 4,5,6,7-Tetrahydroisothiazolo (4,5-c)pyridine derivatives and isomers | H. LUNDBECK A/S (DK) | 1989-10-11 | — | — | EP | disclosed |
| US-4866077-A | TREATMENT OF NERVOUS SYSTEM DISORDERS SUCH AS ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1989-09-12 | — | — | US | disclosed |
| EP-0296721-A2 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1988-12-28 | — | — | EP | disclosed |