Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | SOD3 | P08294 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518724 | 0.72 | CHRM2 (0.50) | CHRM2CHRM3 | |
| SCHEMBL9521006 | 0.72 | CHRM2 (0.50) | CHRM2HTR2AHTR2CHTR2BCHRM3 | |
| SCHEMBL8400708 | 0.72 | CHRM2 (0.66) | CHRM2HTR2AHTR2CHTR2BCHRM3 | |
| SCHEMBL12373979 | 0.67 | HTR2C (0.47) | HTR2C | |
| SCHEMBL7471858 | 0.66 | CHRM2 (0.46) | CHRM2HTR2AHTR2CHTR2BCHRM3 | |
| Hydrochloric Acid SCHEMBL2280238 | 0.66 | HTR2C (0.49) | HTR2C | |
| SCHEMBL6023321 | 0.66 | CHRM2 (1.00) | CHRM2CHRM3 | |
| SCHEMBL8401454 | 0.66 | CHRM2 (0.65) | CHRM2HTR2AHTR2CHTR2BCHRM3 | |
| SCHEMBL8405098 | 0.66 | CHRM2 (0.66) | CHRM2HTR2AHTR2CHTR2BCHRM3 | |
| SCHEMBL10152548 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36374-E | 1,2,3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists | H. LUNDBECK, A/S (DK) | 1999-11-02 | — | — | US | disclosed |
| US-4925858-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1990-05-15 | — | — | US | disclosed |
| US-4866077-A | TREATMENT OF NERVOUS SYSTEM DISORDERS SUCH AS ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1989-09-12 | — | — | US | disclosed |
| EP-0296721-A2 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1988-12-28 | — | — | EP | disclosed |