Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.57 |
| ▸ | PDE4A | P27815 | 3/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | LDHB | P07195 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406024 | 0.73 | PDE4A (1.00) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL12171525 | 0.72 | MYC (0.48) | SYKKMT2APOLBTDP1PRKAG1 | |
| SCHEMBL19330203 | 0.69 | KMT2A (0.52) | PDE4DPDE4BPDE4APDE4CFFAR4 | |
| SCHEMBL29788032 | 0.69 | POLB (0.57) | POLBTDP1PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL2044532 | 0.69 | POLB (0.57) | POLBTDP1PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL930213 | 0.68 | EPHX2 (0.59) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL30162751 | 0.68 | EPHX2 (0.59) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL5179635 | 0.68 | PDE4D (0.56) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL20021958 | 0.68 | CNR1 (0.54) | PDE4DPDE4BPDE4APDE4CFFAR4 | |
| SCHEMBL12949688 | 0.68 | PDGFRB (0.48) | PDE4DPDE4BPDE4APDE4CFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |