Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 1.00 |
| ▸ | HTR1B | P28222 | 20/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | HTR1F | P30939 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473252 | 0.90 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7474143 | 0.87 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL7479541 | 0.84 | HTR1D (0.94) | HTR1DHTR1B | |
| SCHEMBL7479599 | 0.84 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7479048 | 0.84 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7479099 | 0.81 | HTR1D (0.80) | HTR1DHTR1B | |
| SCHEMBL7479104 | 0.81 | HTR1D (0.80) | HTR1DHTR1B | |
| SCHEMBL8814329 | 0.81 | HTR1D (0.80) | HTR1DHTR1B | |
| SCHEMBL7476780 | 0.79 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8567598 | 0.79 | HTR1D (0.73) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998415-A | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors | MERCK SHARP & DOHME LTD. (GB) | 1999-12-07 | — | — | US | claimed |
| US-5998415-A | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors | MERCK SHARP & DOHME LTD. (GB) | 1999-12-07 | — | — | US | disclosed |