Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 18/20 | 1.00 |
| ▸ | GRIK2 | Q13002 | 8/20 | 1.00 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.58 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.58 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.58 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404044 | 1.00 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8404046 | 1.00 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8724517 | 0.89 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8399796 | 0.89 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8724519 | 0.89 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8399799 | 0.89 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8399788 | 0.89 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8724521 | 0.89 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8520059 | 0.85 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| SCHEMBL8520057 | 0.85 | GRIK1 (1.00) | GRIK1GRIK2GRIA4GRIK3GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990165-A | AN UNSATURATED ALPHA-AMINO CARBOXYLIC ACID TO MODIFY NEUROTRANSMISSION BY INTERACTION WITH IONOTROPIC AND MEETABOTROPIC RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; | LILLY, S.A. (ES) | 1999-11-23 | — | — | US | disclosed |
| EP-0867430-A2 | Glutamic acid derivatives and pharmaceutical compositions for the treatment of central nervous system disorders | LILLY S.A. (ES) | 1998-09-30 | — | — | EP | disclosed |