SCHEMBL84051

SCHEMBL84051

FC(F)(F)c1ccccn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
AHR P35869 1/20 0.47
TRPV4 Q9HBA0 1/20 0.44
KDM4E B2RXH2 2/20 0.43
CYP1A2 P05177 2/20 0.43
BLM P54132 2/20 0.43
LMNA P02545 1/20 0.43
POLB P06746 1/20 0.43
CCR1 P32246 1/20 0.43
CCR5 P51681 1/20 0.43
CCR8 P51685 1/20 0.43
METAP1 P53582 1/20 0.43
HIF1A Q16665 1/20 0.43
DOHH Q9BU89 1/20 0.43
P4HTM Q9NXG6 1/20 0.43
GAA P10253 1/20 0.42
MDM2 Q00987 1/20 0.42
LOXL2 Q9Y4K0 2/20 0.42
GABRA1 P14867 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29401687 1.00 SMN1; SMN2 (0.58) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
SCHEMBL29424134 1.00 SMN1; SMN2 (0.58) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
SCHEMBL5041519 1.00 SMN1; SMN2 (0.58) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
Methane SCHEMBL8775730 0.97 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
Bromide SCHEMBL22440321 0.97 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
SCHEMBL28480196 0.97 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
Hydrochloric Acid SCHEMBL18039122 0.97 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
Hydrochloric Acid SCHEMBL30785438 0.97 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
SCHEMBL28002956 0.97 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E
SCHEMBL27951465 0.97 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1AHRTRPV4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3512 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122010824-A Amide derivative containing trifluoromethyl pyridine and synthetic method and application thereof 贵州大学 2026-05-12 CN claimed
EP-4688154-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - Portela & Ca., S.A. (PT) 2026-02-11 EP claimed
EP-4688155-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS Bial-Portela & CA, S.A. (PT) 2026-02-11 EP claimed
US-20260001877-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2026-01-01 US claimed
WO-2025224601-A1 TRPM3 ANTAGONISTS FOR THE TREATMENT OF MIGRAINE AND PAIN BIOHAVEN THERAPEUTICS LTD. (VG) 2025-10-30 WO claimed
WO-2025122636-A1 METHOD FOR THE SYNTHESIS OF ACRYLATE DERIVATIVES Orthobond Corporation (US) 2025-06-12 WO claimed
CN-119080745-B Pyrazole derivative containing trifluoromethyl pyridine biaryl structure, and preparation method and application thereof 南通大学 2025-05-30 CN claimed
WO-2025083630-A1 HETEROAROMATIC COMPOUNDS AS MUSCARINIC M4 RECEPTOR POSITIVE ALLOSTERIC MODULATORS (M4 PAMS) SUVEN LIFE SCIENCES LIMITED (IN) 2025-04-24 WO claimed
CN-114989211-B Hexafluorophosphoric acid complex and synthetic method and application thereof 张家港博威新能源材料研究所有限公司 2025-04-18 CN claimed
CN-119569645-A Trifluoromethyl pyridine derivative and preparation method and application thereof 石河子大学 2025-03-07 CN claimed
EP-0092117-B1 PROCESS FOR PRODUCING CHLORONICOTINIC ACID COMPOUNDS ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-07-15 EP claimed
US-4650875-A CATALYTIC FLUORINATION OF TRICHLOROMETHYL ANALOG THE DOW CHEMICAL COMPANY (US) 1987-03-17 US claimed
US-4590279-A CATALYTIC FLUORINATION OF (TRICHLOROMETHYL)PYRIDINES THE DOW CHEMICAL COMPANY (US) 1986-05-20 US claimed
US-4567273-A MERCURY OR SILVER FLUORINATING AGENT THE DOW CHEMICAL COMPANY (US) 1986-01-28 US claimed
US-4563529-A VAPOR PHASE CATALYTIC FLUORINATION OF PICOLINES OR LUTIDINES ISHIHARA SANGYO KAISHA LTD. (JP) 1986-01-07 US claimed
US-4504665-A Process for producing chloronicotinic acid compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1985-03-12 US claimed
EP-0042696-B1 PROCESS FOR PRODUCING TRIFLUOROMETHYLPYRIDINES ISHIHARA SANGYO KAISHA LTD. (JP) 1983-11-16 EP claimed
EP-0092117-A1 Process for producing chloronicotinic acid compounds ISHIHARA SANGYO KAISHA, LTD. (JP) 1983-10-26 EP claimed
EP-0031218-B1 A 2-AMINO-TRIFLUOROMETHYL-HALOGENOPYRIDINE COMPOUND AND A PROCESS FOR PRODUCING THE SAME ISHIHARA SANGYO KAISHA LTD. (JP) 1983-05-11 EP claimed
EP-0042696-A1 Process for producing trifluoromethylpyridines ISHIHARA SANGYO KAISHA LTD. (JP) 1981-12-30 EP claimed