Malonic Acid Diethyl Ester

Malonic Acid Diethyl Ester

SCHEMBL8406575

CCOC(=O)CC(=O)OCC.O=C(O)CC(=O)O

nearest known ligand 0.79

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.79
MGAM O43451 1/20 0.79
SI P14410 1/20 0.79
MGAM2 Q2M2H8 1/20 0.79
ALDH1A1 P00352 6/20 0.50
TRPA1 O75762 1/20 0.50
LDHA P00338 1/20 0.47
SRR Q9GZT4 1/20 0.47
EGLN1 Q9GZT9 1/20 0.45
LMNA P02545 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ALOX15 P16050 2/20 0.42
SOAT1 P35610 1/20 0.42
HCAR2 Q8TDS4 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Malonic Acid Diethyl Ester SCHEMBL18911581 1.00 GAA (0.79) GAAMGAMSIMGAM2ALDH1A1
Malonic Acid Diethyl Ester SCHEMBL28844893 0.95 GAA (0.79) GAAMGAMSIMGAM2ALDH1A1
Malonic Acid Diethyl Ester SCHEMBL9684546 0.93 GAA (0.68) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL30741390 0.92 GAA (0.74) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL15376 0.92
SCHEMBL13278763 0.90 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL3196229 0.90 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL1068040 0.90 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
Water SCHEMBL2811574 0.90 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL11097044 0.90 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5948945-A Prevention of spontaneous decomposition of gaseous acetylene BASF AKTIENGESELLSCHAFT (DE) 1999-09-07 US claimed
CN-106565455-B Electron level malonic acid 宿迁南翔化学品制造有限公司 2019-08-06 CN disclosed
EP-3387099-A1 FOOD CONTACT SURFACE SANITIZING LIQUID The Clorox Company (US) 2018-10-17 EP disclosed
WO-2017099964-A1 FOOD CONTACT SURFACE SANITIZING LIQUID THE CLOROX COMPANY (US) 2017-06-15 WO disclosed
CN-106565455-A Electronic grade malonic acid 宿迁南翔化学品制造有限公司 2017-04-19 CN disclosed
CN-104086540-A Preparation method for 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS ANADYS PHARMACEUTICALS INC 2014-10-08 CN disclosed
CN-102985159-A method for capturing carbon dioxide UNIV LEEDS 2013-03-20 CN disclosed