Known targets — ChEMBL curated mechanism
CYP11A1CYP11B1CYP11B2CYP17A1ERG11
The experimentally established mechanism targets of Levoketoconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 known ✓ | P05093 | 15/20 | 1.00 |
| ▸ | CYP11B1 known ✓ | P15538 | 14/20 | 1.00 |
| ▸ | CYP11B2 known ✓ | P19099 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 19/20 | 1.00 |
| ▸ | CYP21A2 | P08686 | 16/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 16/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | CYP27B1 | O15528 | 1/20 | 1.00 |
| ▸ | CYP26A1 | O43174 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levoketoconazole SCHEMBL29384825 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL13606596 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL13575830 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL29588034 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Ketoconazole SCHEMBL18258319 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Ketoconazole SCHEMBL8408 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL24312989 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL41473 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL1517472 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 | |
| Levoketoconazole SCHEMBL11213392 | 1.00 | CYP3A4 (1.00) | CYP3A4CYP21A2CYP19A1CYP17A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 83618 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026106952-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | CDG CARE (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026107113-A1 | MODIFIED CELLS FOR PROGRAMMING EXTRA ENVELOPED VIRUSES (EEVs) AND THEIR USE FOR PRODUCING THE EEVs, THE PROGRAMMED EEVs AND USES THEREOF | CALIDI BIOTHERAPEUTICS (NEVADA), INC. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-4744729-A2 | METHODS OF TREATING GASTROINTESTINAL STROMAL TUMORS | Deciphera Pharmaceuticals, LLC (US) | 2026-05-20 | — | — | EP | claimed |
| EP-4149415-B1 | SHAMPOO COMPOSITION COMPRISING ALKYL GLUCOSIDE | PROCTER & GAMBLE (US) | 2026-05-20 | — | — | EP | claimed |
| CN-122057085-A | External auditory canal degradable and self-adaptive drug stent with combined drug release in segmented mode and preparation method thereof | 上海交通大学医学院附属瑞金医院 | 2026-05-19 | — | — | CN | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| WO-2026102345-A1 | METHODS OF ADMINISTERING THE VOLTAGE-GATED POTASSIUM CHANNEL OPENER AZETUKALNER | XENON PHARMACEUTICALS INC. (CA) | 2026-05-15 | — | — | WO | claimed |
| CN-122055142-A | Improved pill design for administration to ruminants and uses thereof | 反刍动物生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| WO-1987002219-A1 | ALPHA TOCOPHEROL-BASED VESICLES | THE LIPOSOME COMPANY, INC. (US) | 1987-04-23 | — | — | WO | claimed |
| US-4659695-A | Method of treatment of prostate cancer | LABRIE FERNAND (CA) | 1987-04-21 | — | — | US | claimed |
| WO-1986005977-A1 | STEROIDAL LIPOSOMES | THE LIPOSOME COMPANY, INC. (US) | 1986-10-23 | — | — | WO | claimed |
| EP-0197571-A2 | Novel derivatives of gamma-cyclodextrin | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-15 | — | — | EP | claimed |
| EP-0196855-A2 | Tioconazole and related compounds for prevention of sexually transmitted diseases and control of herpetic infections | PFIZER INC. (US) | 1986-10-08 | — | — | EP | claimed |
| EP-0180263-A3 | METHOD FOR CONTROLLING VASCULAR WITHERING DISEASES IN PLANTS, ESPECIALLY DUTCH ELM DISEASE | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO (NL) | 1986-07-30 | — | — | EP | claimed |
| EP-0180263-A2 | Method for controlling vascular withering diseases in plants, especially dutch elm disease | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO (NL) | 1986-05-07 | — | — | EP | claimed |
| US-4569935-A | Topical treatment of psoriasis with imidazole antibiotics | UNIVERSITY OF TENNESSEE RESEARCH CORP. (US) | 1986-02-11 | — | — | US | claimed |
| US-4542020-A | CELLULOSE DERIVATIVE HYDROCOLLOID, LOW MELTING BASE | E. R. SQUIBB & SONS, INC. (US) | 1985-09-17 | — | — | US | claimed |
| US-4491588-A | Treatment of psoriasis and seborrheic dermatitis with imidazole antibiotics | UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) | 1985-01-01 | — | — | US | claimed |