Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 6/20 | 0.58 |
| ▸ | USP2 | O75604 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | RORC | P51449 | 3/20 | 0.54 |
| ▸ | RORA | P35398 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | OSBP | P22059 | 2/20 | 0.54 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CDC25A | P30304 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10337844 | 1.00 | NPC1L1 (0.58) | NPC1L1USP2LMNARORCRORA | |
| SCHEMBL9912381 | 1.00 | NPC1L1 (0.58) | NPC1L1USP2LMNARORCRORA | |
| SCHEMBL12125083 | 1.00 | NPC1L1 (0.58) | NPC1L1USP2LMNARORCRORA | |
| SCHEMBL13076780 | 0.90 | OSBP (0.56) | NPC1L1USP2LMNARORCRORA | |
| SCHEMBL6393207 | 0.87 | NPC1L1 (0.51) | NPC1L1USP2LMNARORCRORA | |
| SCHEMBL6389384 | 0.87 | NPC1L1 (0.51) | NPC1L1USP2LMNARORCRORA | |
| SCHEMBL1654511 | 0.85 | GPBAR1 (0.66) | USP2LMNAMEN1KMT2ATP53 | |
| SCHEMBL21137444 | 0.85 | CYP2D6 (0.47) | NPC1L1USP2LMNARORCRORA | |
| SCHEMBL19360942 | 0.85 | GPBAR1 (0.66) | USP2LMNAMEN1KMT2ATP53 | |
| SCHEMBL14568559 | 0.84 | TSHR (0.56) | TP53GPBAR1NR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853194-B2 | Sterol derivatives and their synthesis and use | Chen, Dagang (CN) | 2014-10-07 | — | — | US | disclosed |
| US-8853194-B2 | Sterol derivatives and their synthesis and use | Chen, Dagang (CN) | 2014-10-07 | — | — | US | disclosed |
| US-20120130067-A1 | Sterol Derivatives and Their Synthesis and Use | Chen, Dagang (CN) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130067-A1 | Sterol Derivatives and Their Synthesis and Use | LSS, NR1H3, CYP46A1 | NPC1L1 51/4885USP2 4284/4885LMNA 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.