Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 7/20 | 0.65 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.65 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.63 |
| ▸ | F2 | P00734 | 2/20 | 0.63 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.63 |
| ▸ | PLAU | P00749 | 1/20 | 0.63 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.63 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.63 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.63 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.63 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.63 |
| ▸ | F10 | P00742 | 1/20 | 0.63 |
| ▸ | PLG | P00747 | 1/20 | 0.63 |
| ▸ | S100B | P04271 | 1/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | AOC1 | P19801 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407255 | 0.95 | PRSS1 (0.68) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL7748657 | 0.95 | PRSS1 (0.71) | PRSS1TMPRSS2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL8409943 | 0.93 | PRSS1 (0.69) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL8407185 | 0.92 | PRSS1 (0.64) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL7748746 | 0.91 | PRSS1 (0.74) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL5522432 | 0.89 | PRMT1 (0.75) | PRSS1TMPRSS2PRMT1F2ST14 | |
| Pentamidine SCHEMBL21462087 | 0.89 | PRMT1 (0.75) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL14599520 | 0.89 | PRMT1 (0.75) | PRSS1TMPRSS2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL5526299 | 0.88 | PRSS1 (0.76) | PRSS1TMPRSS2PRMT1F2ST14 | |
| Pentamidine SCHEMBL27820863 | 0.88 | PRMT1 (0.77) | PRSS1TMPRSS2PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |