Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL5866439 | 0.97 | FFAR3 (0.62) | FFAR3TDP1ALDH1A1LCKFYN | |
| Methacrylic Acid SCHEMBL1628181 | 0.97 | FFAR3 (0.62) | FFAR3TDP1ALDH1A1LCKFYN | |
| Methacrylic Acid SCHEMBL27479208 | 0.94 | FFAR3 (0.59) | FFAR3TDP1ALDH1A1LCKFYN | |
| Methacrylic Acid SCHEMBL27552504 | 0.94 | FFAR3 (0.59) | FFAR3TDP1ALDH1A1LCKFYN | |
| Methacrylic Acid SCHEMBL6501619 | 0.89 | FFAR3 (0.53) | FFAR3TDP1ALDH1A1HDAC3HDAC1 | |
| Methacrylic Acid SCHEMBL27547320 | 0.85 | FFAR3 (0.44) | FFAR3TDP1ALDH1A1LCKFYN | |
| Methacrylic Acid SCHEMBL20335186 | 0.85 | TDP1 (0.44) | FFAR3TDP1ALDH1A1LCKFYN | |
| Methacrylic Acid SCHEMBL270686 | 0.85 | TDP1 (0.62) | FFAR3TDP1ALDH1A1LCKFYN | |
| Methacrylic Acid SCHEMBL2581850 | 0.84 | — | — | |
| Propionic Acid SCHEMBL10395289 | 0.84 | FFAR3 (0.71) | FFAR3TDP1ALDH1A1LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985951-A | PHOTOPOLYMERIZABLE COMPOSITION FOR COSMETIC NAIL COATINGS WITH CELLULOSE ESTER OR TRANSESTER, PHOTOINITIATORS AND ETHYLENICALLY UNSATURATED CROSSLINKING AGENTS, EXPOSURE TO ACTINIC RADIATION TO FORM SOLVENT RESISTANT COATING | EASTMAN CHEMICAL COMPANY (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998048769-A1 | UV-CURABLE NAIL COATING FORMULATIONS CONTAINING CELLULOSE ESTERS WITH ETHYLENICALLY UNSATURATED PENDANT GROUPS | EASTMAN CHEMICAL COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |