Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.59 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842216 | 0.85 | PKN1 (0.59) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL3333407 | 0.85 | RHEB (0.68) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL19994470 | 0.85 | RHEB (0.59) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL1842081 | 0.85 | RHEB (0.59) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL28267390 | 0.85 | CHEK2 (0.61) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL20982583 | 0.84 | RHEB (0.70) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL1663535 | 0.83 | KDM4E (0.59) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL8409891 | 0.83 | CHEK2 (0.70) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL5579984 | 0.82 | CHEK1 (0.59) | CHEK2DGAT1KCNH2GUSBCDK5 | |
| SCHEMBL415254 | 0.82 | CHEK1 (0.55) | CHEK2DGAT1KCNH2GUSBCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942532-A | INHIBITORS OF HISTIDINE PROTEIN KINASE; BACTERIA RESISTANT TO OTHER ANTIBIOTICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |
| WO-1999011627-A1 | 2-SUBSTITUTED PHENYL-BENZIMIDAZOLE ANTIBACTERIAL AGENTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-03-11 | — | — | WO | disclosed |