Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 9/20 | 0.56 |
| ▸ | FABP2 | P12104 | 1/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5331306 | 0.87 | PPARA (0.56) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL12777729 | 0.86 | PPARA (0.68) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL10714994 | 0.84 | PPARA (0.61) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL5321702 | 0.82 | PPARA (0.55) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL5322553 | 0.81 | PPARA (0.57) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL24936089 | 0.80 | TSHR (0.58) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL5325047 | 0.79 | PPARA (0.55) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL787522 | 0.78 | PPARA (0.67) | PPARAMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL2034762 | 0.77 | SLC6A4 (0.53) | CYP2C19CYP1A2CYP2D6TSHRALDH1A1 | |
| SCHEMBL2031199 | 0.77 | SLC6A4 (0.53) | CYP2C19CYP1A2CYP2D6TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5927283-A | TREATING DISEASES INVOLVING OXYGEN DEFICIENCY, IN WOUND HEALING, AND IN RESTORING OXYGEN AFFINITY OF STORED BLOOD. | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-07-27 | — | — | US | disclosed |
| US-5872282-A | MAINTAIN OXYGEN AFFINITY IN BLOOD WHEN STORED | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-02-16 | — | — | US | disclosed |
| US-5731454-A | Allosteric modifiers of hemoglobin useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1998-03-24 | — | — | US | disclosed |
| US-5705521-A | Use of allosteric hemoglobin modifiers in combination with radiation therapy to treat carcinogenic tumors | THE CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1998-01-06 | — | — | US | disclosed |
| US-5677330-A | THERAPY HYPOXIA, HYPOTHERMIA, ISCHEMIC, WOUNDS, ULCERS, TISSUE TRANSPLANTS, SESPIS | THE CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1997-10-14 | — | — | US | disclosed |
| US-5591892-A | CARBOXYALKOXYPHENYL SUBSTITUTED INDANES | CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1997-01-07 | — | — | US | disclosed |