Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415411 | 0.92 | PTPN1 (0.41) | PDCD1CD274BACE1PTPN1BIRC5 | |
| SCHEMBL8415409 | 0.92 | PTPN1 (0.41) | PDCD1CD274BACE1PTPN1BIRC5 | |
| SCHEMBL8411325 | 0.83 | CD274 (0.38) | PDCD1CD274BACE1PTPN1PTGER1 | |
| SCHEMBL7563015 | 0.82 | CD274 (0.37) | PDCD1CD274BACE1PTPN1PTGER1 | |
| SCHEMBL4287188 | 0.82 | PTGER3 (0.50) | PDCD1CD274BACE1PTGER1PTGER3 | |
| SCHEMBL1451542 | 0.82 | PTGER3 (0.50) | PDCD1CD274BACE1PTGER1PTGER3 | |
| SCHEMBL9433677 | 0.80 | PTGER1 (0.41) | PDCD1CD274BACE1BIRC5PIM1 | |
| SCHEMBL9433685 | 0.80 | PTGER1 (0.41) | PDCD1CD274BACE1BIRC5PIM1 | |
| Hydrochloric Acid SCHEMBL9433691 | 0.80 | PTGER3 (0.49) | PDCD1CD274BACE1PTGER1PTGER3 | |
| SCHEMBL3667411 | 0.75 | BACE1 (0.55) | BACE1PTPN1PTGER1PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934256-A1 | PROCESS FOR THE PRODUCTION OF CYANOCINNAMAMIDES | AlliedSignal Inc. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016501-A1 | PROCESS FOR THE PRODUCTION OF CYANOCINNAMAMIDES | ALLIEDSIGNAL INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| US-5654465-A | Process for the production of cyanocinnamamides | ALLIEDSIGNAL INC. (US) | 1997-08-05 | — | — | US | disclosed |