SCHEMBL8415428

SCHEMBL8415428

O=C(O)CCc1ccc(N2CCN(CCC34CCN(CC3)CC4)C2=O)cc1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 1/20 0.56
HDAC1 Q13547 9/20 0.47
ITGB3 P05106 1/20 0.41
ITGA2B P08514 1/20 0.41
RAB9A P51151 1/20 0.40
DRD2 P14416 4/20 0.38
DRD3 P35462 4/20 0.38
PPARD Q03181 1/20 0.38
PPARA Q07869 1/20 0.38
FFAR1 O14842 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8414010 0.99 S1PR1 (0.55) S1PR1HDAC1ITGB3ITGA2BRAB9A
Hydrochloric Acid SCHEMBL7393682 0.92 S1PR1 (0.53) S1PR1HDAC1ITGB3ITGA2BRAB9A
SCHEMBL8414173 0.87 S1PR1 (0.47) S1PR1HDAC1RAB9ADRD2DRD3
SCHEMBL8417146 0.77 S1PR1 (0.83) S1PR1HDAC1FFAR1
Hydrochloric Acid SCHEMBL7384212 0.76 S1PR1 (0.64) S1PR1HDAC1ITGB3ITGA2BRAB9A
SCHEMBL7392921 0.74 S1PR1 (0.58) S1PR1HDAC1ITGB3ITGA2BRAB9A
Hydrochloric Acid SCHEMBL7397569 0.73 S1PR1 (0.54) S1PR1HDAC1ITGB3ITGA2BRAB9A
SCHEMBL7394485 0.73 S1PR1 (0.54) S1PR1HDAC1ITGB3ITGA2BDRD2
Hydrochloric Acid SCHEMBL7395305 0.73 S1PR1 (0.53) S1PR1HDAC1ITGB3ITGA2BDRD2
Hydrochloric Acid SCHEMBL7384228 0.72 S1PR1 (0.53) S1PR1HDAC1ITGB3ITGA2BRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5880284-A HAVING ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASES-INHIBITING EFFECTS DR. KARL THOMAE GMBH (DE) 1999-03-09 US claimed
US-5681841-A PREVENTION CELL AGGREGATION KARL THOMAE GMBH (DE) 1997-10-28 US disclosed