Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415662 | 1.00 | MEN1 (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9722020 | 0.89 | SMN1; SMN2 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9722015 | 0.89 | SMN1; SMN2 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9625931 | 0.87 | MEN1 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9626007 | 0.87 | MEN1 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29673014 | 0.84 | CYP1A2 (0.55) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL25117781 | 0.81 | MEN1 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9788863 | 0.81 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29362256 | 0.81 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL15378255 | 0.81 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866611-A | PHENOXYPROPYLAMINE INHIBITORS OF SQUALENE SYNTHESE, USEFUL IN TREATING DISEASES IN WHICH A LOWERING OF CHOLESTEROL IS DESIRABLE. | ZENECA LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |
| EP-0589018-A1 | AMINES AS INHIBITORS OF SQUALENE SYNTHASE | ZENECA LIMITED (GB) | 1994-03-30 | — | — | EP | disclosed |
| WO-1993020807-A1 | AMINES AS INHIBITORS OF SQUALENE SYNTHASE | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |