Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.75 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | YES1 | P07947 | 2/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8417324 | 0.85 | SRC (1.00) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8809924 | 0.85 | SRC (0.62) | SRCYES1 | |
| SCHEMBL8417252 | 0.85 | SRC (0.73) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8815972 | 0.81 | SRC (0.79) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8815818 | 0.80 | SRC (0.76) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8421232 | 0.76 | SRC (1.00) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8421353 | 0.76 | SRC (0.61) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8816150 | 0.74 | SRC (0.79) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8419343 | 0.73 | SRC (0.59) | SRCYES1 | |
| SCHEMBL7216556 | 0.72 | SRC (0.58) | SRCPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012903-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING THE BINDING OF PROTEINS CONTAINING AN SH2 DOMAIN TO COGNATE PHOSPHORYLATED PROTEINS | WARNER-LAMBERT COMPANY (US) | 1997-04-10 | — | — | WO | claimed |
| US-5922697-A | Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins | WARNER-LAMBERT COMPANY (US) | 1999-07-13 | — | — | US | disclosed |
| WO-1997012903-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING THE BINDING OF PROTEINS CONTAINING AN SH2 DOMAIN TO COGNATE PHOSPHORYLATED PROTEINS | WARNER-LAMBERT COMPANY (US) | 1997-04-10 | — | — | WO | disclosed |