Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8227864 | 0.86 | HRH3 (0.67) | HRH3KCNH2HTR1AGRM5 | |
| SCHEMBL3653090 | 0.85 | HRH3 (0.64) | HRH3KCNH2HTR1A | |
| SCHEMBL3654447 | 0.85 | HRH3 (0.74) | HRH3KCNH2GRM5 | |
| SCHEMBL3646531 | 0.85 | HRH3 (0.61) | HRH3KCNH2HTR1A | |
| SCHEMBL3646448 | 0.85 | HRH3 (0.61) | HRH3KCNH2HTR1A | |
| SCHEMBL3655508 | 0.84 | HRH3 (0.75) | HRH3KCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL4535011 | 0.84 | HRH3 (0.62) | HRH3KCNH2HTR1A | |
| SCHEMBL4540984 | 0.84 | HRH3 (0.76) | HRH3KCNH2HTR1A | |
| SCHEMBL3650636 | 0.84 | HRH3 (0.76) | HRH3KCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL3771831 | 0.84 | HRH3 (0.60) | HRH3KCNH2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069300-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069300-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH3, HRH2 | HRH3 2/4885KCNH2 508/4885HTR1A 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.