Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.71 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.65 |
| ▸ | NPC1L1 | Q9UHC9 | 5/20 | 0.60 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.57 |
| ▸ | OSBP | P22059 | 4/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | RORC | P51449 | 2/20 | 0.57 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | GBA1 | P04062 | 2/20 | 0.54 |
| ▸ | UGCG | Q16739 | 2/20 | 0.54 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | CRYAB | P02511 | 1/20 | 0.49 |
| ▸ | HMGCR | P04035 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 1/20 | 0.49 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21413966 | 0.86 | POLA1 (0.78) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL17149877 | 0.86 | POLA1 (0.84) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL20104891 | 0.86 | POLA1 (0.70) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL16300435 | 0.86 | POLA1 (0.70) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL16300437 | 0.86 | POLA1 (0.70) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL13028361 | 0.86 | POLA1 (0.70) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL20104856 | 0.86 | POLA1 (0.70) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL13028383 | 0.86 | POLA1 (0.70) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL17149881 | 0.86 | POLA1 (0.77) | POLA1CYP46A1NPC1L1NR1H3OSBP | |
| SCHEMBL1707118 | 0.85 | POLA1 (0.76) | POLA1CYP46A1NPC1L1NR1H3OSBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5993823-A | BETWEEN 10 AND 40 AMINO ACIDS AND AT LEAST ONE ANTIGENIC DETERMINANT, ALSO COMPRISING A CHAIN FROM PIMELAUTIDE, TRIMEXAUTIDE, HEXADECANOIC ACID, 2-AMINO-HEXADECANOIC ACID, STEROID GROUPS AND DERIVATIVES THEREOF | INSTITUT PASTEUR DE LILLE (FR) | 1999-11-30 | — | — | US | disclosed |