Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 20/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 16/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.79 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636519 | 0.89 | HDAC3 (0.82) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL4415910 | 0.87 | HDAC3 (0.76) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL21435753 | 0.86 | HDAC3 (1.00) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL6640133 | 0.86 | HDAC3 (0.77) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL6637885 | 0.84 | HDAC3 (0.73) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL24051501 | 0.83 | HDAC3 (0.72) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL24051782 | 0.82 | HDAC3 (0.68) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL24051502 | 0.81 | HDAC3 (0.70) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL17141755 | 0.81 | HDAC3 (1.00) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL3001447 | 0.81 | HDAC3 (0.81) | HDAC3HDAC1HDAC2NCOR2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113754591-B | HDAC, JAK and BET three-target inhibitor and preparation method and application thereof | 山东大学 | 2024-01-05 | — | — | CN | disclosed |
| CN-116867776-A | Histone deacetylase inhibitor and application thereof | 微境生物医药科技(上海)有限公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-115073424-A | Histone deacetylase inhibitor and application thereof | 微境生物医药科技(上海)有限公司 | 2022-09-20 | — | — | CN | disclosed |
| US-5955506-A | ACETAMIDOBENZAMIDE COMPOUNDS FOR TREATMENT OF PARKINSON'S DISEASE | CENTAUR PHARMACEUTICALS, INC. (US) | 1999-09-21 | — | — | US | disclosed |