Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.62 |
| ▸ | CA12 | O43570 | 2/20 | 0.62 |
| ▸ | CA9 | Q16790 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA3 | P07451 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA6 | P23280 | 1/20 | 0.62 |
| ▸ | CA5A | P35218 | 1/20 | 0.62 |
| ▸ | CA7 | P43166 | 1/20 | 0.62 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.62 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | NT5E | P21589 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | TYR | P14679 | 1/20 | 0.58 |
| ▸ | DAO | P14920 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1698232 | 0.95 | MAOB (0.63) | MAOBCA12CA9CA1CA3 | |
| SCHEMBL30023 | 0.93 | HPGD (0.60) | MAOBCA12CA9CA1CA3 | |
| SCHEMBL31418947 | 0.93 | HPGD (0.60) | MAOBCA12CA9CA1CA3 | |
| Hydrochloric Acid SCHEMBL2291019 | 0.91 | HPGD (0.58) | MAOBCA12CA9CA1CA3 | |
| Ammonia Solution, Strong SCHEMBL27428848 | 0.91 | HPGD (0.58) | MAOBCA12CA9CA1CA3 | |
| Methacrylic Acid SCHEMBL31073510 | 0.89 | MAOB (0.56) | MAOBCA12CA9CA1CA3 | |
| Phosphonic Acid SCHEMBL28608612 | 0.88 | HPGD (0.56) | MAOBCA12CA9CA1CA3 | |
| Pyrene SCHEMBL28909258 | 0.84 | HSD17B3 (0.56) | MAOBCA12CA9CA1CA3 | |
| Serine SCHEMBL1352954 | 0.83 | MAOB (0.48) | MAOBCA12CA9CA1CA3 | |
| Acetic Acid SCHEMBL3657787 | 0.82 | MAOB (0.56) | MAOBCA12CA9CA1CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962291-A | MONOCLONAL ANTIBODY CAPABLE OF HYDROLYZING A SUBSTRATE; HAS TWO BINDING SITES: ONE FOR FREE METAL ION, ONE FOR SUBSTRATE | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 1999-10-05 | — | — | US | disclosed |