Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7155122 | 0.93 | TDP1 (0.45) | DHODHSTAT3LMNAMAPK1MMP1 | |
| SCHEMBL9447559 | 0.88 | DHODH (0.39) | DHODHSTAT3LMNAMAPK1CA1 | |
| SCHEMBL8423991 | 0.88 | STAT3 (0.44) | DHODHSTAT3LMNAMAPK1ALDH1A1 | |
| SCHEMBL1940854 | 0.86 | STAT3 (0.43) | DHODHSTAT3LMNAMAPK1ALDH1A1 | |
| SCHEMBL1942190 | 0.86 | STAT3 (0.43) | DHODHSTAT3LMNAMAPK1ALDH1A1 | |
| SCHEMBL1940851 | 0.86 | STAT3 (0.43) | DHODHSTAT3LMNAMAPK1ALDH1A1 | |
| SCHEMBL5473718 | 0.84 | STAT3 (0.41) | DHODHSTAT3LMNAMAPK1CA1 | |
| SCHEMBL5473721 | 0.84 | STAT3 (0.41) | DHODHSTAT3LMNAMAPK1CA1 | |
| SCHEMBL5473716 | 0.84 | STAT3 (0.41) | DHODHSTAT3LMNAMAPK1CA1 | |
| SCHEMBL8206059 | 0.84 | DHODH (0.36) | DHODHSTAT3LMNAMAPK1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886190-A | REACTING GLYCEROL-1,3-DITOSYLATE-2-O-ACETYLATE WITH 2-NITROIMIDAZOLE TO FORM CHEMICAL INTERMEDIATE 1-(2'-NITRO-1'-IMIDAZOLYL)-2-O-ACETYL-3-O-TOSYLPROPANOL IN PRESENCE OF DIMETHYLFORMAMIDE AND CESIUM CARBONATE | WALLACE SIDNEY (US) | 1999-03-23 | — | — | US | disclosed |
| US-5728843-A | POSITRON EMISSION TOMOGRAPHY(PET) TO DIFFERENTIATE METABOLICALLY ACTIVE HYPOXIC TUMOR CELLS | WALLACE TECHNOLOGIES (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1995009844-A1 | RAPID SYNTHESIS AND USE OF 18F-FLUOROMISONIDAZOLE AND ANALOGS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1995-04-13 | — | — | WO | disclosed |