Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | IL6 | P05231 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428812 | 0.95 | HRH3 (0.69) | HRH3MEN1KMT2ADNM1MAOB | |
| SCHEMBL8411264 | 0.81 | HRH3 (0.64) | HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8573167 | 0.81 | HRH3 (0.64) | HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8411263 | 0.81 | HRH3 (0.64) | HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8592053 | 0.79 | MEN1 (0.57) | HRH3MEN1KMT2AAPPALDH1A1 | |
| SCHEMBL8592055 | 0.79 | MEN1 (0.57) | HRH3MEN1KMT2AAPPALDH1A1 | |
| SCHEMBL1598877 | 0.76 | MEN1 (0.66) | HRH3MEN1KMT2AALDH1A1ACHE | |
| SCHEMBL7362683 | 0.76 | MEN1 (0.66) | HRH3MEN1KMT2AALDH1A1ACHE | |
| SCHEMBL79547 | 0.76 | MEN1 (0.66) | HRH3MEN1KMT2AALDH1A1ACHE | |
| SCHEMBL8425020 | 0.73 | KMT2A (0.56) | HRH3MEN1KMT2AMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902812-A | Pharmaceutical piperazine compounds | XENOVA LIMITED (GB) | 1999-05-11 | — | — | US | disclosed |
| US-5891877-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0745069-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021829-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |