SCHEMBL8425320

SCHEMBL8425320

COc1ccc2ccc(S(=O)(=O)N(C)[C@H]3CCN(Cc4cc(C(=N)N)cs4)C3=O)cc2c1

nearest known ligand 0.78

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KLK6 Q92876 4/20 0.78
F10 P00742 16/20 0.75
F2 P00734 12/20 0.75
PLG P00747 1/20 0.75
PLAT P00750 1/20 0.75
PROC P04070 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7423366 0.99 KLK6 (0.76) KLK6F10F2PLGPLAT
Trifluoroacetic Acid SCHEMBL2332758 0.94 KLK6 (0.70) KLK6F10F2PLGPLAT
Trifluoroacetic Acid SCHEMBL2332752 0.94 KLK6 (0.70) KLK6F10F2PLGPLAT
Trifluoroacetic Acid SCHEMBL2326893 0.85 F10 (0.69) KLK6F10F2PLGPLAT
SCHEMBL2330145 0.84 KLK6 (0.65) KLK6F10F2PLGPLAT
SCHEMBL2332489 0.83 F10 (0.97) KLK6F10F2PLGPLAT
SCHEMBL8425318 0.82 F10 (0.80) KLK6F10F2PLGPLAT
SCHEMBL8425322 0.82 F10 (0.80) KLK6F10F2PLGPLAT
Trifluoroacetic Acid SCHEMBL2326764 0.82 KLK6 (0.89) KLK6F10F2PLGPLAT
Trifluoroacetic Acid SCHEMBL2326762 0.82 KLK6 (0.89) KLK6F10F2PLGPLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5958918-A Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N- (aminominomethyl)phenylalkyl!-azaheterocyclylamide compounds RHONE-POULENC RORER PHARMACEUTICALS INC. 1999-09-28 US disclosed