Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | IL6 | P05231 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426199 | 1.00 | SERPINE1 (0.55) | SERPINE1HRH3PPARGMAOBTNKS | |
| SCHEMBL8494225 | 0.89 | SERPINE1 (0.67) | SERPINE1HRH3MAOBTNFIL6 | |
| SCHEMBL6378369 | 0.89 | SERPINE1 (0.67) | SERPINE1HRH3MAOBTNFIL6 | |
| SCHEMBL8495273 | 0.89 | SERPINE1 (0.59) | SERPINE1HRH3MAOBTNFIL6 | |
| SCHEMBL8495305 | 0.89 | SERPINE1 (0.59) | SERPINE1HRH3MAOBTNFIL6 | |
| SCHEMBL8496917 | 0.86 | SERPINE1 (0.55) | SERPINE1HRH3MAOBKDM4EALDH1A1 | |
| SCHEMBL8496911 | 0.86 | SERPINE1 (0.55) | SERPINE1HRH3MAOBKDM4EALDH1A1 | |
| SCHEMBL8495145 | 0.85 | SERPINE1 (0.54) | SERPINE1HRH3MAOBTNKSTNF | |
| SCHEMBL8495150 | 0.85 | SERPINE1 (0.54) | SERPINE1HRH3MAOBTNKSTNF | |
| SCHEMBL8428821 | 0.85 | SERPINE1 (0.51) | SERPINE1HRH3MAOBTNKSTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| US-5891877-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |