Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 3/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426392 | 1.00 | SERPINE1 (0.65) | SERPINE1CASP3SENP8SENP7SENP6 | |
| SCHEMBL8424308 | 0.86 | MAPT (0.50) | SERPINE1SENP7MEN1KMT2ANPC1 | |
| SCHEMBL8424305 | 0.86 | MAPT (0.50) | SERPINE1SENP7MEN1KMT2ANPC1 | |
| SCHEMBL6372616 | 0.80 | SERPINE1 (1.00) | SERPINE1NPC1MAPTRAB9ACYP1A2 | |
| SCHEMBL6372620 | 0.80 | SERPINE1 (1.00) | SERPINE1NPC1MAPTRAB9ACYP1A2 | |
| SCHEMBL9026253 | 0.77 | MAPT (0.47) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6373541 | 0.77 | SERPINE1 (0.72) | SERPINE1NPC1MAPTRAB9A | |
| SCHEMBL9026245 | 0.77 | MAPT (0.47) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6373545 | 0.77 | SERPINE1 (0.72) | SERPINE1NPC1MAPTRAB9A | |
| SCHEMBL29506662 | 0.76 | MEN1 (0.61) | CASP3SENP8SENP7SENP6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891877-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |