Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.53 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8334354 | 0.99 | POLB (0.69) | POLBALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL8428558 | 0.84 | NPSR1 (0.55) | POLBALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL6360091 | 0.83 | POLB (1.00) | POLBALDH1A1HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL8333013 | 0.83 | NPSR1 (0.53) | POLBALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL8428571 | 0.81 | NPSR1 (0.52) | POLBALDH1A1TAS1R3TAS1R1TP53BP1 | |
| SCHEMBL8430502 | 0.81 | NPSR1 (0.51) | POLBALDH1A1NPSR1TP53GAA | |
| Hydrochloric Acid SCHEMBL8336186 | 0.81 | NPSR1 (0.51) | POLBALDH1A1TAS1R3TAS1R1TP53BP1 | |
| SCHEMBL8428607 | 0.81 | NPSR1 (0.69) | POLBALDH1A1TAS1R3TAS1R1NPSR1 | |
| SCHEMBL8426329 | 0.81 | NPSR1 (0.54) | POLBALDH1A1TAS1R3TAS1R1NPSR1 | |
| Hydrochloric Acid SCHEMBL8336410 | 0.80 | NPSR1 (0.50) | POLBALDH1A1NPSR1TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791577-B1 | Ortho-substituted benzylguanidines, process for their preparation and their use as medicament or diagnostic agent as well as medicament containing them | HOECHST AG (DE) | 1999-11-03 | — | — | EP | claimed |