Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272247 | 1.00 | RECQL (0.50) | RECQLUSP2SMN1; SMN2HSD17B10TGM2 | |
| SCHEMBL4913097 | 1.00 | RECQL (0.50) | RECQLUSP2SMN1; SMN2HSD17B10TGM2 | |
| SCHEMBL13436643 | 0.89 | HSD17B10 (0.46) | SMN1; SMN2HSD17B10TGM2NR1H2HPGD | |
| SCHEMBL13462042 | 0.89 | HSD17B10 (0.46) | SMN1; SMN2HSD17B10TGM2NR1H2HPGD | |
| SCHEMBL4919124 | 0.89 | HSD17B10 (0.46) | SMN1; SMN2HSD17B10TGM2NR1H2HPGD | |
| SCHEMBL13567830 | 0.84 | RECQL (0.53) | RECQLUSP2SMN1; SMN2HSD17B10TGM2 | |
| SCHEMBL8426484 | 0.83 | RECQL (0.54) | RECQLUSP2SMN1; SMN2HSD17B10TGM2 | |
| SCHEMBL13567876 | 0.83 | RECQL (0.54) | RECQLUSP2SMN1; SMN2HSD17B10TGM2 | |
| SCHEMBL13567832 | 0.83 | RECQL (0.54) | RECQLUSP2SMN1; SMN2HSD17B10TGM2 | |
| SCHEMBL8272250 | 0.83 | RECQL (0.54) | RECQLUSP2SMN1; SMN2HSD17B10TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671076-B2 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2010-03-02 | — | — | US | disclosed |
| US-20080119464-A1 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBVIE INC. | 2008-05-22 | — | — | US | disclosed |
| US-7348346-B2 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2008-03-25 | — | — | US | disclosed |
| US-20050215603-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBOTT LABORATORIES | 2005-09-29 | — | — | US | disclosed |
| US-20050209249-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBVIE INC. | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119464-A1 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | DPP4, DPP3, DPP7 | RECQL 2381/4885USP2 1791/4885SMN1; SMN2 4790/4885 |
| US-20050209249-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | DPP4, DPP3, DPP7 | RECQL 2381/4885USP2 1791/4885SMN1; SMN2 4790/4885 |
| US-20050215603-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | DPP4, DPP3, DPP7 | RECQL 2381/4885USP2 1791/4885SMN1; SMN2 4790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.