Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fulvestrant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 10/20 | 0.76 |
| ▸ | ESRRA | P11474 | 9/20 | 0.76 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.76 |
| ▸ | PPARG | P37231 | 1/20 | 0.76 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.76 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | ESRRB | O95718 | 8/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fulvestrant SCHEMBL408338 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| Fulvestrant SCHEMBL14340043 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| Fulvestrant SCHEMBL22356606 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| Fulvestrant SCHEMBL23134939 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| Fulvestrant SCHEMBL20448785 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| Fulvestrant SCHEMBL23760281 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL24511123 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL23963146 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| Fulvestrant SCHEMBL22667548 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| Fulvestrant SCHEMBL7803375 | 1.00 | ESR1 (0.76) | ESR1ESRRAESR2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178255-A1 | COMBINATIONS COMPRISING METAP2 INHIBITORS FOR THE TREATMENT OF CANCER | SYNDEVRX, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| US-5986115-A | STEROIDS WITH FLUORO GROUPS AND ETHER OR ESTER GROUPS | SCHERING AG (DE) | 1999-11-16 | — | — | US | disclosed |