Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404364 | 0.77 | MAPT (0.44) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL20563419 | 0.74 | MAPT (0.42) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL2056250 | 0.74 | MAPT (0.42) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL9394238 | 0.74 | KDM4E (0.42) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL18069886 | 0.74 | MAPT (0.42) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL18876006 | 0.74 | CYP2A6 (0.42) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL2498909 | 0.72 | KDM4E (0.45) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL29352476 | 0.72 | KDM4E (0.45) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL22504295 | 0.72 | KDM4E (0.42) | MAPTKDM4EALDH1A1GAAHTT | |
| SCHEMBL24344559 | 0.71 | KDM4E (0.40) | MAPTKDM4EALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922733-A | ADMINISTERING TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY, DEPRESSION, EPILEPSY, OBSESSIVE COMPULSIVE DISORDERS, ANOREXIA, BULIMIA AND ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0770076-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996002537-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-02-01 | — | — | WO | disclosed |