Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL6 | P05231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428374 | 1.00 | SERPINE1 (0.51) | SERPINE1MAOBHRH3APPDNM1 | |
| SCHEMBL8424976 | 0.94 | SERPINE1 (0.49) | SERPINE1MAOBHRH3MAOA | |
| SCHEMBL8424982 | 0.94 | SERPINE1 (0.49) | SERPINE1MAOBHRH3MAOA | |
| SCHEMBL8495305 | 0.91 | SERPINE1 (0.59) | SERPINE1MAOBHRH3DNM1KDM4E | |
| SCHEMBL8495273 | 0.91 | SERPINE1 (0.59) | SERPINE1MAOBHRH3DNM1KDM4E | |
| SCHEMBL8496911 | 0.88 | SERPINE1 (0.55) | SERPINE1MAOBHRH3DNM1KDM4E | |
| SCHEMBL8496917 | 0.88 | SERPINE1 (0.55) | SERPINE1MAOBHRH3DNM1KDM4E | |
| SCHEMBL8490810 | 0.86 | SERPINE1 (0.60) | SERPINE1MAOBHRH3DNM1KDM4E | |
| SCHEMBL6378369 | 0.86 | SERPINE1 (0.67) | SERPINE1MAOBHRH3DNM1TNF | |
| SCHEMBL8495460 | 0.86 | SERPINE1 (0.54) | SERPINE1MAOBHRH3DNM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | claimed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| US-5891877-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |