Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 3/20 | 0.52 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.49 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.45 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428514 | 1.00 | CACNA1B (0.52) | CACNA1BHSP90B1TRAP1SERPINE1HPGD | |
| SCHEMBL8424360 | 0.83 | PRMT5 (0.46) | CACNA1BSERPINE1HPGDMAPTLMNA | |
| SCHEMBL8424366 | 0.83 | PRMT5 (0.46) | CACNA1BSERPINE1HPGDMAPTLMNA | |
| SCHEMBL8428423 | 0.82 | DRD3 (0.53) | CACNA1BHPGDLMNAHRH3 | |
| SCHEMBL8428415 | 0.82 | DRD3 (0.53) | CACNA1BHPGDLMNAHRH3 | |
| SCHEMBL6378369 | 0.78 | SERPINE1 (0.67) | SERPINE1HRH3 | |
| SCHEMBL8494225 | 0.78 | SERPINE1 (0.67) | SERPINE1HRH3 | |
| SCHEMBL8495273 | 0.78 | SERPINE1 (0.59) | SERPINE1HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8495305 | 0.78 | SERPINE1 (0.59) | SERPINE1HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8492151 | 0.77 | SERPINE1 (0.55) | SERPINE1HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | claimed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| US-5891877-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |