Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.70 |
| ▸ | HTR1B | P28222 | 20/20 | 0.70 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | HTR1F | P30939 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427576 | 0.91 | HTR1D (0.69) | HTR1DHTR1BHTR2AHTR1A | |
| SCHEMBL8427579 | 0.91 | HTR1D (0.69) | HTR1DHTR1BHTR2AHTR1A | |
| SCHEMBL8431783 | 0.91 | HTR1D (0.78) | HTR1DHTR1B | |
| SCHEMBL7480569 | 0.91 | HTR1D (0.78) | HTR1DHTR1B | |
| SCHEMBL8427610 | 0.91 | HTR1D (0.78) | HTR1DHTR1B | |
| SCHEMBL8429795 | 0.91 | HTR1D (0.65) | HTR1DHTR1B | |
| SCHEMBL8427507 | 0.89 | HTR1D (0.63) | HTR1DHTR1B | |
| SCHEMBL8427964 | 0.88 | HTR1D (0.61) | HTR1DHTR1B | |
| SCHEMBL8429821 | 0.87 | HTR1D (0.65) | HTR1DHTR1B | |
| SCHEMBL8427478 | 0.87 | HTR1D (0.65) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861245-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | claimed |
| WO-1997019073-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | claimed |
| US-5973156-A | Piperidine and tetrahydropyridine derivatives | MERCK SHARP & DOME LTD. (GB) | 1999-10-26 | — | — | US | disclosed |
| EP-0861245-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997019073-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |