SCHEMBL8428897

SCHEMBL8428897

O=C(Nc1ccc(O)c2c1C(=O)c1c(O)ccc(NC(=O)c3ccccc3)c1C2=O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
MMP14 P50281 1/20 0.60
KCNMA1 Q12791 2/20 0.58
HDAC1 Q13547 3/20 0.54
HDAC2 Q92769 2/20 0.54
CYP1A2 P05177 3/20 0.53
TSHR P16473 1/20 0.53
CASP3 P42574 1/20 0.51
GAA P10253 1/20 0.50
MDM4 O15151 1/20 0.49
TP53 P04637 1/20 0.49
HDAC3 O15379 1/20 0.49
MAPK1 P28482 1/20 0.49
POLB P06746 1/20 0.49
HPGD P15428 1/20 0.49
MAPT P10636 2/20 0.47
PABPC1 P11940 1/20 0.47
CCR6 P51684 1/20 0.47
ATM Q13315 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3415157 0.92 MEN1 (0.72) MEN1KMT2AMMP14KCNMA1HDAC1
SCHEMBL3407714 0.90 MEN1 (0.61) MEN1KMT2AMMP14KCNMA1HDAC1
SCHEMBL9165154 0.85 MEN1 (0.56) MEN1KMT2AMMP14KCNMA1CYP1A2
SCHEMBL6419867 0.83 MEN1 (0.82) MEN1KMT2AMMP14HDAC1HDAC2
SCHEMBL30544874 0.83 MEN1 (0.82) MEN1KMT2AMMP14HDAC1HDAC2
SCHEMBL11847585 0.82 MEN1 (0.58) MEN1KMT2AMMP14KCNMA1HDAC1
SCHEMBL11606895 0.82 CYP1A2 (0.67) MEN1KMT2AMMP14HDAC1HDAC2
SCHEMBL11293297 0.82 MEN1 (0.62) MEN1KMT2AMMP14KCNMA1HDAC1
SCHEMBL11139038 0.81 MEN1 (0.58) MEN1KMT2AMMP14KCNMA1CYP1A2
SCHEMBL9174800 0.79 MEN1 (0.76) MEN1KMT2AMMP14HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5942292-A Spacer for liquid crystal display and liquid crystal display made by using the same KAO CORPORATION (JP) 1999-08-24 US disclosed