Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431038 | 0.98 | KDM4E (0.62) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL8429278 | 0.98 | KDM4E (0.62) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL8427271 | 0.97 | KDM4E (0.64) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL8427187 | 0.93 | KDM4E (0.74) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL8429585 | 0.92 | CYP1B1 (0.56) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL8427276 | 0.91 | CYP1B1 (0.56) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL8429312 | 0.89 | POLB (0.52) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL4397722 | 0.88 | KDM4E (0.70) | KDM4EPOLBCYP2C9HPGDCYP2C19 | |
| SCHEMBL8305990 | 0.87 | MAOB (0.66) | KDM4EPOLBALDH1A1CYP1A2MAOB | |
| SCHEMBL10472448 | 0.86 | CYP1A2 (0.63) | KDM4EPOLBCYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0803503-B1 | Acids and esters of diosmetin and pharmaceutical compositions containing them | ADIR (FR) | 1999-11-03 | — | — | EP | disclosed |
| US-5792789-A | TREATING HYPERPERMEABILITY AND INFLAMMATION | ADIR ET COMPAGNIE (FR) | 1998-08-11 | — | — | US | disclosed |
| EP-0803503-A1 | Acids and esters of diosmetin and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-10-29 | — | — | EP | disclosed |