⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homocysteine SCHEMBL936365 | 0.78 | PTGS1 (0.62) | — | |
| L-Homocysteine SCHEMBL35837 | 0.78 | — | — | |
| Homocysteine SCHEMBL28927454 | 0.78 | PTGS1 (0.62) | — | |
| Homocysteine SCHEMBL35836 | 0.78 | — | — | |
| L-Homocysteine SCHEMBL936366 | 0.78 | PTGS1 (0.62) | — | |
| SCHEMBL7196813 | 0.78 | — | — | |
| SCHEMBL4632678 | 0.78 | — | — | |
| Homocysteine SCHEMBL601148 | 0.78 | — | — | |
| SCHEMBL16033448 | 0.77 | — | — | |
| SCHEMBL58409 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4663239-A2 | PEGYLATED CYSTATHIONINE BETA SYNTHASE FOR ENZYME THERAPY FOR TREATMENT OF HOMOCYSTINURIA | Travere Therapeutics Switzerland GmbH (CH) | 2025-12-17 | — | — | EP | disclosed |
| EP-3990005-B1 | PEGYLATED CYSTATHIONINE BETA SYNTHASE FOR ENZYME THERAPY FOR TREATMENT OF HOMOCYSTINURIA | TRAVERE THERAPEUTICS SWITZERLAND GMBH (CH) | 2025-08-27 | — | — | EP | disclosed |
| US-12364765-B2 | Pegylated cystathionine beta synthase for enzyme therapy for treatment of homocystinuria | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2025-07-22 | — | — | US | disclosed |
| US-20240417428-A1 | POLYPEPTIDE FOR INHIBITING TRPM8 AND USE THEREOF | ZHEJIANG UNIVERSITY (CN) | 2024-12-19 | — | — | US | disclosed |
| CN-116840197-A | 2' -O-methyltransferase activity detection method, kit and application | 中国科学院苏州生物医学工程技术研究所 | 2023-10-03 | — | — | CN | disclosed |
| CN-116448842-A | Homocysteine electrochemical sensor and preparation method and application thereof | 中南民族大学 | 2023-07-18 | — | — | CN | disclosed |
| US-20230220443-A1 | CHARACTERIZATION OF S-ADENOSYL-L-METHIONINE-CONSUMING ENZYMES WITH 1-STEP EZ-MTASE: A UNIVERSAL COUPLED-ASSAY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-07-13 | — | — | US | disclosed |
| EP-4188917-A1 | PREPARATION OF ERDOSTEINE OR A DERIVATIVE THEREOF USING A CONTINUOUS FLOW PROCESS | EDMOND PHARMA S.R.L. (IT) | 2023-06-07 | — | — | EP | disclosed |
| US-20220290116-A1 | CYSTATHIONINE BETA-SYNTHASE ENZYME THERAPY FOR TREATMENT OF ELEVATED HOMOCYSTEINE LEVELS | TRAVERE THERAPEUTICS SWITZERLAND GMBH (CH) | 2022-09-15 | — | — | US | disclosed |
| US-20220265835-A1 | PEGYLATED CYSTATHIONINE BETA SYNTHASE FOR ENZYME THERAPY FOR TREATMENT OF HOMOCYSTINURIA | ORPHAN TECHNOLOGIES, LTD. (CH) | 2022-08-25 | — | — | US | disclosed |
| CN-114786712-A | PEGylated cystathionine beta synthetase for use in enzyme therapy for the treatment of homocystinuria | 特拉维尔治疗瑞士有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-114630673-A | Cystathionine beta-synthase enzyme therapy for treating elevated homocysteine levels | 特拉维尔治疗瑞士有限公司 | 2022-06-14 | — | — | CN | disclosed |
| EP-3990005-A1 | PEGYLATED CYSTATHIONINE BETA SYNTHASE FOR ENZYME THERAPY FOR TREATMENT OF HOMOCYSTINURIA | Travere Therapeutics Switzerland GmbH (CH) | 2022-05-04 | — | — | EP | disclosed |
| WO-2022023929-A1 | PREPARATION OF ERDOSTEINE OR A DERIVATIVE THEREOF USING A CONTINUOUS FLOW PROCESS | EDMOND PHARMA S.R.L. (IT) | 2022-02-03 | — | — | WO | disclosed |
| CN-104558119-B | YAP albumen inhibits polypeptide and its application | 上海宝恒泓康生物技术有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-100404688-C | High specificity homocysteine assays for biological samples | ANTICANCER INC (US) | 2008-07-23 | — | — | CN | disclosed |
| CN-1268978-A | High specificity homocysteine assays for biological samples | ANTICANCER INC (US) | 2000-10-04 | — | — | CN | disclosed |
| US-6007792-A | CHELATE COMPOUNDS LABELED WITH TECHNETIUM-99M, RHENIUM-186, OR RHENIUM-188; TUMOR IMAGING | DIATIDE, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0820313-A2 | RADIOLABELED PEPTIDES FOR DIAGNOSIS AND THERAPY | Diatide, Inc. (US) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996030055-A2 | RADIOLABELED PEPTIDES FOR DIAGNOSIS AND THERAPY | DIATIDE, INC. (US) | 1996-10-03 | — | — | WO | disclosed |